A great Filter is upon us

Gene-editing is becoming increasingly easy to use and it is fairly cheap.
Gene-editing tool-kits can be bought without any sort of licens or affiliating, it's commercial available for the average person both in terms of price and availability.

We have an increasing understanding of what specific DNA segments does - we figure out what a particular gene code for and it's role in the cell.
This information is also becoming increasingly easy for an average reader to absorb.

Inevitable, the average person will be capable of editing the genome of an organism. The already existing data-bases on what a gene does, will expand, making it possible for the average person to choose the properties he/she wants to give the cells.

Bacteria are cells, they can be gene-edited just as easily as any other cells. This include bacteria such as Anthrax and Plague. They exist naturally all over the world, and they can be harvested and grown, and gene-edited.
This is how most Anthrax attacks are made, some guy just grows the bacteria - there isn't any "illegal market", it is just a guy with some petri-dish.

The average person will be able to create extremely potent infectious disease; give them an array of different properties through genetic modification.

An average guy will easily be able to take out hundreds of millions of lives, and there are a lot of sick people in this world.

This is the first great-filter we will encounter in our life-time.

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Other urls found in this thread:

theguardian.com/science/2017/dec/24/josiah-zayner-diy-gene-editing-therapy-crispr-interview
the-odin.com/gene-engineering-kits/
twitter.com/NSFWRedditImage

As a guy just about to start a masters in genetics, allow meto assuage your worries.

No, a random dick of the street is not going to be able to make a hell plague in the next fifty years.

But a university grad student think tank? Yeah. That's going to be doable.

As the first man-made epidemic will emerge, by a "lone-wolf", freedom will die.

1984, will become a reality, where the government tries to control your thoughts and action, in order to prevent the people from doing harm to others.

It will depend on how user-friendly it will become. If you have a "baking-recipe" specifying how to insert any gene into an organism, and you have a list of genes to choose from with defined properties.

A random person could increase the pathogenicity of a given bacteria.

I'm starting a masters in molecular biology in September. Are you as anxious as me? It's the waiting I can't stand

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Mate it's killing me. I've done nothing but drink and stress. My degree wasn't as stress inducing as this shit

Dude what about CRISPR, can I soon inject some stuff that makes me grow more muscles, change skin colour and extend my life???

we eugenics wars now

expect the poos to genetically engineer Khan noonien singh any day now, who will go on to rule all of Eurasia for a decade

you thought super power by 2020 was only a meme

There is a guy who modified his myostatin Gene.

He's going to be a muscular hulk without exercise.
He's going to pass this trait down to his children too.
It's going to be amazing.

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When do you think we’ll get to a point where modifying a certain gene will change your body overnight, or over the course of a week? I want to study genetics but I’m not sure. Is it worth it? Researching sounds interesting to me.

>inb4 Christcucks who want humanity doomed to oblivion come in whining about 'playing God' etc

theguardian.com/science/2017/dec/24/josiah-zayner-diy-gene-editing-therapy-crispr-interview

>"Despite warnings from the US Food and Drug Administration (FDA) that selling gene therapy products without regulatory approval is illegal, Zayner sells kits that allow anyone to get started with basic genetic engineering techniques, and has published a free guide for others who want to take it further and experiment on themselves."

>Edit the genes relating to specific cells in your body, imbalances caused when the cells die and reproduce with the new genes over time cause cancers and turn people into The Fly.

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Fortunately, those who make these propositions are generally NEETs on Jow Forums who can't stop masturbating for long enough to learn anything actually materially applicable IRL.

>average guy doing gene engineering
gee, I wonder why we need all these universities, when average Joe can apparently do anything

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stop your fear mongering, we are not nearly that close yet

ya you can alter genes for different parts of your body, but we have no idea how those overal edits will affect the body on a whole

not to mention if we get too close it would probably be shut down

As far as I can tell he's just injecting myostatin inhibition CRISPRs via syringe into his muscles on a weekly or so basis.

This could work over the course of a few months/year. Really the better way to do this, I think, would be with an adenovirus carrier. The process would be much faster and far more cells would be infected.

As far as I can tell the dude is literally just shooting CRISPRs into random parts of his muscles and hoping some of them get into some cells. This shit is going to take forever

HAHA WOW NEET YEAH YOU TOTALLY JUST FIGURED IT OUT!!

"Imbalances" can better be defined as the carcinogenic effects of life, which break down DNA regulatory mechanisms/genes over the course of an organisms lifetime and lead to non-apoptopic cells. This is cancer, and this can be corrected with gene therapy.

Applied gene therapy is essentially immortality, so long as the organism does not die of trauma.

For anyone interested, here's where you can buy gene editing kits. To get the plasmids (the rings of RNA that CRISPR Cas9 uses as instructions to perform the edits), you'll have to order them online from another company for an average of 10 cents per base pair, but once you know the specific sequence you want it's as easy as pasting the sequence into a text box and entering your credit card information, waiting a few days/weeks, and viola! Some basic lab skills required, or you can just follow the instructions to the letter and it should turn out fine.
the-odin.com/gene-engineering-kits/
I for one embrace the chaos. Now that the box is opened, nothing less than total annihilation can put the lid back on it.

If that's his method, then by god will he be waiting a while. There's a reason why all the academic labs use AAVs.

This is possible using adenovirus vectors. We're already here, it's just very expensive because it's new tech.

Modified viruses carrying CRISPR are used to infect large portions of the body, re-engingeering every cell they manage to infiltrate.

This is what viruses have been doing for billions of years. They infect a cell and re-program it's genome such that the cell essentially becomes a manufacturing facility for new virus, and nothing else. This is how viruses work.

Gene-editors simply modify viruses such that they infect cells with desired CRISPRs instead of the baggage which makes them pathological.

A good example of what you're talking about is a product called Luxterna, made by Spark Therapeutics in Philadelphia. It's a one time gene therapy cure for blindness. Blindness in a large number of individuals is caused by the deficieny in a gene which codes for a single protein in the eye. This is easily corrected via a simple gene editing procedure. Patients are infected (in the eye) with a virus carrying the CRISPR correction, and that's really it.

Current price is $400,000 per eye, but this is only because it's a brand new procedure. This inflation is completely artificial. In 10 years such a procedure will/should cost next to nothing, unless artificial inflation is maintained.

But the process itself is so easy. Besides manufacturing viruses, which I'm not so familiar with, buying and using CRISPR itself is so cheap and easy literally anyone can do it out of there garage with a few pieces of basic lab equipment.

Indeed

massive lol
that feel when capitalism has brought the general population to the level that they know gene editing exists, and they know that bacteria exist, but they don't know how infection works, how contagion spreads, how bacterioculture works, or how successful any of these techniques (including gene editing) is

but instead of them being cynical and critical and assuming these people are incapable, the enlightenment has convinced everyone that scientists are god, and that everything we market as a possible breakthrough is going to change the world forever(tm)

what a world man
what a world

crispr doesn't work as well as you think lmao

Viruses are more lethal amongst all bio-hazard, bacterial/fungus
Radiological hazard is the biggest threat for earth's life I think, then biological with a virus
And some terrorists with basical knowledge in biology would have hard times to find what they need for biological engeneering (again, Yersinia pestis or C. botulinum is laughable compared to infuenzae potential)

Spoken like a true fedora with a ten inch dildo up his rectum.

It does if you use AAV's or proper delivery mechanisms. It doesn't if you do what Zayner is doing, which is literally just jabbing himself with syringes and shooting CRISPRs into whatever.

oh no, the anus has the highest concentration of nerve endings in the entire male body
oh no, better never touch it, it might feel good~
oh no~
read a fucking journal
reversion is a problem
turns out we're not that knowledgeable in a field that's less than 10 years old, weird, huh

>the anus has the highest concentration of nerve endings in the entire male body

Sounds like homo popsci shit to me

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ITT
Faggots who have no idea how genetics actually work, attempting to predict the future of humanies most complex technologies.
KYS plebs. The average successful fellowship applicant has 9 first author papers with high impact factors.
You have no chance. Find a shitty niche specialty and pray its boring enough that few students go down that path in the future. Ie bioinformatics

Wouldn't it be weird if the great filter is impassable because of the behaviour of a generation born after we were able to nuke the world.
Wouldn't it be weird if when we needed the greatest people we could produce, we got boomers instead.
WOULDN'T IT BE WEIRD IF BOOMERS ARE THE REASON WE WON'T GET PAST THE NEXT GREAT FILTER

Yo crazy idea,
Maybe we haven't found/ been found by aliens because space is so incredibly vast the chance even with FTL, hundreds of advanced species, and sprawling civilizations, the odds a particular star gets visited is nil
If life were common, an advanced civilization would have found enough primitive ones that it would not care to put resources into an exhaustive search.

Spoken like a true homo. Kill yourself

Only faggot in here who seems to have any idea what hes talking about

he did it to make a point. he knows it wont actually change his body

>irrelevant image that has tangential linguistic relation to the subject
>buzzword salad
your diagram doesn't show nerve endings, retard

12 Monkeys

Gladly and for the common knowledge you proved your point providing us a schema or a scientifical work
End yourself faggot

Just enjoy your ignorance.

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>first life was cyanobacteria
>almost completely wiped out by global ice age
>second life was sea creatures and lizards on the land
>almost completely wiped out by gigantic magma field
>third era of life was dinosaurs
>almost completely wiped out by asteroid
>fourth era of life is mammals and man dominates the land
>???

Something will happen. It's just a matter of time.

We have already conquered the Great Filter. We are the first.

>Born too late to explore the Americas on a boat
>Born just in time to see humanity begin its great ascension to the stars

We are close. The vision is there, and the technological capabilities exist to get us around the solar system.

As human population continues to exponentially rise, so will our advancements in science, and our need for resources. We will expand upward, seizing the mineral-rich rocks and worlds, melting them down into stepping stones for human progress.

And as we turn our gaze ever outward, we may hope to make our future brighter than all the stars in the universe.

The conquest for the fabled Galactigates has only just begun.

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How come everything I try, I'm told some variation of this shit? I just want a decent job

>almost completely wiped out by jewish degeneracy that lead to a world war and finally destroyed Earth

>Cheap, unlicensed, "gene-editing" "tool kits" for pregnant women
Yeah that sounds totally safe. Good luck.

>a schema
are you having a hard time coming up with enough words to sound intellectual
do they make dictionaries where you're from?

>first life was cyanobacteria
omg lol

Great filters don't exist as aliens don't exist. The real problem is AI. It will consume everything. Read Nick Land.

Dude, we have literally free and somewhat accesible for a normie capabilities of building all sorts of malicious software - just download a compiler, pirate a book and go forth. Yet there aren't that many hackers, especially those who do the research and cracks, and their attacks, though potentially devastating, are still nowhere there.
You over-estimate mental capabilities, curiocity and maliciousness of an average person.

Only way you can get past it is by stopping to babysit all third world subhumans from africa

>Russian admitting being a hacker
Imagine my shock.

Civilizations tend to destroy themselves. The more technology they have, the more damage they will provoke at their ending.

Great filtoor thread?

>You over-estimate mental capabilities, curiocity and maliciousness of an average person.
Perhaps, the Kaczynski'es of this world seems to be far apart, and even he was driving by something else than "malic".

schema
NOUN
1technical A representation of a plan or theory in the form of an outline or model.

‘a schema of scientific reasoning’


as I said, kill yourself

'First era of life was largely'

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Kaczynski was based as fuck. All Jow Forums people should read his manifesto. It's good information to keep in mind.

Bump because this thread seems to be more interesting than the Plebbit-tier threads we see daily.

what could possibly go wrong?

>Kaczynski was based as fuck. All Jow Forums people should read his manifesto. It's good information to keep in mind.
Yep, where Kaczynski and pic related may have gone wrong is our capability improve technology. The biggest problem humanity has at the moment is population growth and retards who refuse to accept humanity is still just a part of ecosystem.

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