Kike is derived from the hebrew word for circle, which is the mark many jews made on their immigration papers coming into america (instead of an "x" for their signature). like many other racial slurs, it came from immigration officers who used it as short-hand for a population group entering the country.
It would be hilarious if jews started freaking out and whining about being called circles. People would also get the red pill of knowing where the word kike originated from