Megadosing Vitamin D3

You're gonna end up with a vitamin A deficiency. Either decrease the dose or start eating liver.

Best to take them at different times of day: D3 in morning/first meal, K2 afternoon or evening.
Both with fat containing meals that also have a decent amount of calcium and magnesium.

Injection would probably be better for super-dosing. A one-off thing like a B12 injection some athletes use.

Nah bruh, there's studies of people taking 500,000+ IU in a day and suffering no negative consequences. I think caution is good, but docs are just trying to scare people, bruh:

vitamindwiki.com/tiki-index.php?page_id=326

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I did the UV light treatments too. It was awful for many reasons. They start you off at an INCREDIBLY low exposure. It's like 30-45 seconds of low dose UV-A? I think. They are really cautious not to sunburn you and because of that they start you off extremely low dose and move you up in very small increments. Every time I went to the dermatologist it was at least an hour+ affair between parking, waiting to be called in, commute, etc. and to go through all of that just for a 45 second exposure was a complete waste of time. It takes MONTHS before you get any reasonable dosage and thats going I think 2x a week -- It's a fucking huge time commitment for little gains.

Rant aside, you'll make it bro. One other thing that helped me was gabapentin. I had the worst fking itching possible until I got prescribed gabapentin for unrelated nerve damage. I was taking 900mg doses of it and it completely took away all itching. It was the only thing that let me sleep at night. I don't think doctors prescribe it for psoriasis but it was a miracle for me

what an extreme coincidence, I started taking 50,000 UI today to treat a severe vitamin D deficiency. had symptoms of arthritis, extreme joint pain coupled with exhaustion. doc put me on the super dose once a week every week for the next four months. I've been looking into it a good bit and can't find any actual evidence of there being risk, so long as you're vigilant and take it as prescribed.

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Dang, that is interesting. Good luck to us bro! Are you taking 50,000 all at once? How are you spacing your dose throughout the week?

Thanks dude. the capsules I'm taking are one dose of the 50,000 all at once. supposed to take one pill once a week every week for the next four months, and have follow up appointments to track my bloodwork and make sure I get to a healthy range again.

Holy fuck, I just found this:

newsweek.com/vitamin-d-may-help-treat-sunburns-626845

Holy fuck, this connects inflammation and immune response to vitamin D! Basically, there was a study where people were artificially sunburned, and then given either placebos or various doses of vitamin d per day.

Those who took placebo had worse burns, and those who took 50,000, 100,000 or even 200,000 IU of D3 per day had the least inflammation (with 200,000 have the greatest reduction in inflammation)...

This is so interesting. I burn like a motherfucker in the sun. My skin gets bright red. I also have immune issues with the psoriasis, and live in a cokd rainy clinate with low lifetime sun exposure. I wonder if pretty much all of my health problems come down to having low vitamin d3? It must be! That's why I have bad sunburns, that's why I have psoriasis.

Even the other user said getting sunburned helped his psoriasis. What if it wasn't the sun burn per se, but his bodies' reaction to it by producing D3 that regulated his immune system to stop the psoriasis

It all makes so much sense now!!! I might legitimately be onto something, I just never connected the dots until today.

Here is another article about overdosing D3. Supposedly, taking 60,000 IU daily for several months can result in overdose, but even then, I've read other sources that said even higher doses than that were ok.

mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/vitamin-d-toxicity/faq-20058108

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>"We found benefits from vitamin D were dose-dependent," said Kurt Lu, MD, senior author on the study and Assistant Professor of Dermatology at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center. "We hypothesize that vitamin D helps promote protective barriers in the skin by rapidly reducing inflammation. What we did not expect was that at a certain dose, vitamin D not only was capable of suppressing inflammation, it was also activating skin repair genes."

>The trial is the first to describe acute anti-inflammatory benefits from taking vitamin D. According to the authors, despite widespread attention given to vitamin D deficiency, "there is a lack of evidence demonstrating that intervention with vitamin D is capable of resolving acute inflammation." By measuring gene activity in the biopsies, the researchers also uncovered a potential mechanism behind how vitamin D aids skin repair. The results suggest vitamin D increases skin levels of an anti-inflammatory enzyme, arginase-1. The enzyme enhances tissue repair after damage and helps activate other anti-inflammatory proteins.

I know that feel bro. Same here, my hair started to thin and my joints would click. I finished two weeks of pills a while back. Hair went back to being thick. Need to follow up with hospital.

Reminder
Too much vit D is toxic and causes hypercalcemia

Did you even read the links? Give a dosage or I'll assume you're some kind of shill, faggot.

Take Magnesium too dude

>hypervitaminosis D doesn't exist
>SOURCE: A FUCKING SHILL

50,000IU per day is not a problem if it is not done for a long time.

Vitamin D is normaly created in the summer and stored in the liver so you have some over winter.

The proper way to supplement Vit D. is to take blood test (around 30bucks on amazon) and calculate how many I.U. you need to reach max level.

I'm taking around 80,000IU per day currently to reach my target at about 90ng/ml, which is around the highest natural level, a normal level for people in tropical regions and has the highest effect on cancer prevention.

When you are an average guy in the nothern hemisphere, working all day inside and only having a few sunbaths in the summer - your Vit D levels will be at around the minimum or critically low (my first blood test was critically low)

This pic makes my peepee confused.

Integrative pharmacist here. There are plenty of studies showing remission of auto immune diseases with mega dose vitamin d therapy. It's definitely not a guarantee but having your levels checked is a good place to start. I wouldn't want to try it without being able to get lab values. The most we ever recommend without labs is 50,000 units twice weekly for a couple of weeks, then scale back to once weekly after that. It takes about 3 months for d3 levels to level off. Just go slow with it and try to get your levels to around 70.

Also, for anyone taking the 50,000 unit prescription, try and find the D3 over the counter instead. It's a strange situation where the over the counter D3 is more effective than the D2 you get with a prescription.

Oh I didn't know clicking joints was associated with Vit d deficiency. My knees used to click when doing kicks at karate. On to vitamin d for me then

Based, thanks user.

>K2 + D3 combo pills @ 5000 IU
So I guess that's 125 mcg D3 and probably a lot less mcg K2?

Terapeutic doses of K2 used to improve bone density in elderly women used 45000 mcg. Yes, that's a huge amount compared to your pills.
ncbi.nlm.nih.gov/pubmed/10227010
In the west, where they are reluctant to promote vitamins or even make a difference between K1 and K2 (since none of them can be patented), one medicinal indicated the most optimal bone formation process requires at least 1000 mcg/day. (But they didn't go on to say that modern humans need an optimal process.)

D3 overdose happens over a prolonged time. The body can store D3 quite efficiently so elderly sometimes receives huge injections every 6 months, instead of having to eat pills on a dailiy basis.
K2 overdose doesn't seem possible. If you eat a lot of rotten food you probably get all you need. If you have a fridge, like most people these days, you probably don't.
K2 can convert into K1 in case you lack. I have seen claims, but never any form of research or theoretical pathway, that K1 can be turned into K2.

Getting less than optimal amounts of K2 is no big deal unless you take huge amounts of D3.
Lacking K2 the D3 will "clog up" your system causing hypercalcemia.

Interesting post. Would indicate that to cure psoriasis the wavelength is very important.

This bro knows his shit

Yeah I tried the coimbra protocol on my own.

Had regular blood tests for calcium, d3, PTH, etc. 40k IU a day for months had me at roughly 2* the top end of the reference range for D3. Took all the supplements with it too, zinc, b vitamins, etc.

Did not work. My kidneys now too have reduced function, even with a diet that massively restricted my calcium intake.

It's not the answer man. Was taking over a MG of k2 daily too FWIW.

>tfw when your oldest daughter has a nice ass

weird, i just started taking d3 a week ago after reading that german study about how even a small dose can raise your test about 5%. Am combining that with a lot of seafood for the extra zinc. i don't know if these are actual effects but i feel a lot more energetic in the morning and kind of super horny all the time (noporn, still the occasional fap though).

Interesting. What condition were you trying to ameliorate? Also, sounds like you od'd and got kidney problems. Sounds like a blood test before and during this process is the smart move.

>tried to administer large doses of something on my own
>fucked it up
>lol it must not work
have you considered that, perhaps, a qualified practitioner such as a doctor would be able to do their job correctly and have saved you permanent debilitating side effects?

im thinking of trying it this winter, im in the uk (aka no real sunlight 4-6 months a year) so wondering what kind of effects i can expect

im already running trt so at least i have that covered

I'm taking 2000 IU a day, will this do anything for me?

It's fine. Vit D deficiency is usually treated with a week of 100k IUs daily then normal supplementation with 10k IUs.

Vit D levels are tightly regulated in the blood, most of it, about 500-1000k ius is stored in the liver. It's how people got through winters before Vit D supps.

checked

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there's so much positivity in this thread it must be the vitamin D

>Literally head to toe covered in it, worse than any pic on google
My mother also has severe psoriasis like you do. When she started going outside more, the condition started to improve, so you may be on to something.

I wish you the best in the future, user.

Damn, 50,000 is a lot. I cruise on 10,000 every day, but I also spend a lot of time outside

I think the shills in this thread are the ones recommending we take a whole bottle of vitamin d pills everyday

OH no

Mine gets better every summer, and worse every winter. The reason tanning beds don't work very well is that they have manly UVA rather than UVB, which is what you need to treat psoriasis.

Yeah, I quit screwing around with the light treatments too for the same reason.
You can buy a light yourself for at home though, but I think they'e expensive, and you might need a prescription for them to sell it to you.

Wasn't there an user a couple of years ago that ended up disabled due to taking insane doses of vitamines?

psoriasis.

had blood tests before, during, and throughout. Also was taking high dose magnesium.

Yeah, too much calcium when your D3 circulating levels are too high is a massive problem, even the k2 isn't enough (according to the doctor who made the protocol).

It simply did nothing for psoriasis.

This paper has the most comprehensive theory w/ treatment protocol I can find for it.

ncbi.nlm.nih.gov/pubmed/29908580

B3 [nicotinic acid] is a lot more fun.

it was vit B and K that fucked him up. i remember the thread

Thanks for posting bro. I've experimented with bile acids (ox bile) and quercetin supplementation recently. I must say I saw no ameliorative effect while on this regimen, but considering the results of this study, I'd consider trying again at a greater dose. I plan on continuing the d3 supplementation for a few more days at 50k IU a day, then I'll taper to 10k a day.

Ah nice man, I have too. I've used TUDCA @ 500-1500mg/day for a few months too, improved my alkaline phosphatase levels and (subjectively) improved my fat digestion, but unfortunately again no improvement.

I think it's pretty important to get a hold of fungal/bacterial overgrowth for some people, the Ely paper makes a note of ensuring to treat it before the rest of the protocol will do it's work.

At this point I have given perhaps 20 ideas a fair whack over a period of 3 years, dietary/supplemental/UVA+B. Good luck clearing it with the Ely paper. For whatever it's worth, I am currently moving on to this -
earthclinic.com/cures/art-solbrig-psoriasis-protocol.html

I pretty much always keep new ideas in the pipeline - and I have read it all. The sheer amount of ways that people have successfully treated it can be overwhelming. If you take the time to look at the page I just posted, Art has gone through something similar.

Best of luck going forward man, don't buy into the idea that you can't put it in remission/cure it. I was diagnosed ~20 years ago, I managed to clear myself of it entirely for a 2 year period - all the while I was able to eat/drink pretty much anything, massive amounts of gluten and other refined shit too.

Post link

Same poster again, don't know how to navigate this board.

If you want to go deeper into the rabbit hole, check out Art Ayers at coolinginflammation.

He suspects gut dysbiosis sits at the root of most autoimmune diseases. Antibiotics, certain foods, etc can throw it out and start a cascade. No doubt genetics and other environmental factors play in too. The problem seems to be how to return it to a healthier state. Ayers believes most probiotics are ineffective, as is raw dairy products (for a couple of reasons). He believes the way forward is in either fermented vegetables and/or taking in bacteria from your environment - dirt, kissing babies, washing your hands less, animals - and ultimately a fecal matter transplant.

It's worth a poke around his site. I'm leaning towards the idea that the reason many diets seem to work for people or lessen symptoms is because their gut and immune system is impaired, whereas otherwise healthy people simply don't need to take the precaution.

Thanks man, really appreciate the input. I think the gut connection is a solid lead. I've been taking tonnes of different probiotics, with no real impact on my psoriasis. Maybe I need to try other things.

50k is an insane dose and one that really shouldn't be taken unless you're severely deficient and an endocrinologist tells you to.

Measure your vitamin D levels of you aren't sure.

I take 5k-10k a day, but monitor my vitamin D levels and adjust accordingly. I aim for 50ng/dl

No worries bro, hopefully you find something of some use in it.

I found similar with the probiotics too - I simply don't think they get to proliferate before they're destroyed.

This be sure to take K high doses of D3 can lead to issues of you don't but otherwise would recommend.